If you have not seen the Family Guy Star Wars Special, you are missing out!
Especially if you have not watched any of the episodes with the commentary on. The commentary is quite funny and entertaining, although there are times when it gets kind of awkward.The commentary gives you some very insightful information about the whole episode.
In the Blue Harvest episode, there is a scene as pictured above, where R2D2 played by Cleveland and C3PO played by Quagmire are smoking a joint. R2D2 asks 3CPO if the empire is going to fall. 3CPO responds by saying "I... I... dont know Man." 3CPO then asks "How are you doing right now?" and R2D2 says "Good. Why?" 3CPO then confesses that he is having sort of a "mini freak out".
In the commentary, Seth Macfarlane explains how that scene is a reference to a time when he called Alec Kulkin after smoking some of his weed. Alec came over to Seth's house and they smoked some of Alec's weed. Alec had reassured him that the weed was totally legit. After Alec left, Seth called him and asked how he was feeling right now and if he had made it home ok because he was not feeling so good. Seth explains how he thought he had to keep his arms moving constantly otherwise he would become paralyzed.